Effects of the N-Ras Oncogene on the Expression of Other Cellular Genes in CO25 Myoblast Cells
نویسندگان
چکیده
Transformation of fibroblast cells by v-abl oncogene involved overexpression of the c-myc (5) or of the cellular protein p53 (6). Two proto-oncogenes, cmyc and c-K-ras, have been shown to cooperate in the transformation of secondary rat embryo fibroblasts (7). Oncogenic activation of c-myc occurs mainly through constituve and elevated expression of its gene product and generally requires cooperation with at least one additional oncogene, such as ras or bcl-2 (8,9).
منابع مشابه
STUDY OF HMGA2 GENE INHIBITION WITH SPECIFIC SHRNA AND SIRNA AND INVESTIGATION OF CORRESPONDING EFFECTS ON DOWNSTREAM GENE EXPRESSION IN MDA-MB-231 CANCER CELLS: A BIOINFORMATIC AND EXPERIMENTAL STUDY
Background & Aims: The use of siRNA to silence gene expression is increasingly expanding today. The aim of this study is to bioinformatically and experimentally investigate the inhibition of the HMGA2 gene and its corresponding effects on downstream genes expression rate in MDA-MB-231 cancer cell treated by shRNA and siRNA specific to HMGA2. Materials & Methods: To perform this bioinformatic a...
متن کاملنقش اسید ایکوزاپنتاانوئیک(EPA) بر بیان ژن گیرنده آلفای فعالشده در پروکسیزومهای در حال تکثیر (PPAR)
Introduction: Defect in the cholesterol homeostasis in macrophage as well as converting them to foam cells is one of the most important factors in the initiation and progression of atherosclerosis. Many genes and transcription factors like Peroxisome Proliferators Activated Receptors are involved in cholesterol homeostasis in these cells. N-3 fatty acids are one of the most important factors re...
متن کاملThe Effect of Curcumin on GLUT4 Gene Expression as a Diabetic Resistance Marker in C2C12 Myoblast Cells
Objective: Adipocyte and skeletal muscle are important tissues which contribute the development and progression of metabolic disorder. Insulin has a major regulatory function on glucose metabolism in these tissues by redistributing glucose transporter (GLUT4) from intracellular vesicles to the cell surface. Today, due to the side effects of chemical medications attendance to herbal medicines is...
متن کاملEffects of Crocin Down-Regulation on Enzymatic Antioxidant Profile in C2C12 Cells
such as the process of cellular respiration, which is scavenged by enzymatic and non-enzymatic antioxidant systems. Intake of antioxidants from food sources has always been considered in nutrition research. Therefore, the aim of the present study was to investigate antioxidant effects of crocin on the expression profile of genes involved in the enzymatic antioxidant systems in muscle cells. Ma...
متن کاملThe effects of cytotoxic concentration of testosterone, progesterone and estradiol on anti-metastasis CD82/KAI1 expression level in brain glioblastoma cancer cells
Background: Studies have shown that sexual steroids can affect metastasis in cancer cells of nervous system at cellular and molecular level; however, the cellular and molecular mechanism of sexual steroids action on metastasis in cancer cells of nervous system is unclear in many cases. This study aimed at investigating the effects of cytotoxic dose of testosterone, progesterone and estradiol on...
متن کامل